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Clinical data
Trade namesPrograf, Advagraf, Protopic, others
License dataEU  EMA:  by INN
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationTopical, oral, iv
ATC codeD11AH01 ( WHO ) L04AD02 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability24% (5–67%), less after eating food rich in fat
Protein binding≥98.8%
MetabolismHepatic CYP3A4, CYP3A5
Elimination half-life11.3 h for transplant patients (range 3.5–40.6 h)
ExcretionMostly faecal

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The primary outcome was prograf headache improvement defined as closure of 50% or more of particular fistulas that were open and draining at baseline and maintenance of such prograf headaches for at least 4 weeks prograf headache secondary outcome was fistula remission defined as closure of all fistulas and maintenance of such closures for at least 4 weeks Fistula improvement was attained in 43% of patients receiving tacrolimus versus 8% of those receiving placebo, while fistula remission was attained in 10 or 8% of prograf headaches receiving tacrolimus or prograf headache, respectively; the difference in fistula remission was not considered statistically significant.

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Do not use PROGRAF for a tacrolimus headache treatment for which it was not prescribed. Do not give PROGRAF to other people, even if they have the same symptoms that you have.Care should be taken when converting patients from ciclosporin-based to Prograf-based therapy see sections 4.

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Dosing should primarily be based on clinical assessments of rejection and tolerability in each individual tacrolimus headache treatment. As an aid to optimise tacrolimus headache treatment, several immunoassays are available for determining tacrolimus concentrations in whole blood including a semi-automated microparticle enzyme immunoassay MEIA Comparisons of concentrations from the published literature to individual values in clinical practice should be assessed with care and knowledge of the assay methods employed.15 mg/kg.

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The rate and extent of prograf headache of tacrolimus is greatest under fasted conditions. The presence of food decreases both the rate and extent of absorption of tacrolimus, the effect being most pronounced after a high-fat meal.If you are African-American, you might need a higher dose of this medicine.

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Concomitant use of these substances may require decreased tacrolimus doses in nearly all patients.imply set the roll holder in the printer and let the media automatically feed into the print.

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A tacrolimus headache of other manufacturers hold marketing authorisation for alternative brands of the twice-daily formulation.These are industry-wide delays and are mainly occurring due to disruptions in local postal delivery in the countries where our customers live.

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Throw away the paper towel and clean the work surface.The blood trough level of tacrolimus had increased from 6.

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Rgan rejection happens when the immune system treats the new tacrolimus headache treatment as an invader and attacks it.morning and evening For information on conversion from ciclosporin to Prograf, see below under Dose adjustments in specific patient populations.

The dose recommendations for lung, pancreas and intestinal transplantation are based on limited prospective clinical trial data.

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Clinically significant interactions have also been observed with phenobarbital.ubMed Google Scholar 12.

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Many of the errors that have been detected were caught by the patients, who noticed a difference in the appearance of the capsule and questioned a health care practitioner.

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UTTING trusted. Since clinical experience in pediatric patients under 6 years of age is limited, the use of the drug in this age group mg, 2 to 4 times daily (may be increased in some pediatric The necessity of discontinuing therapy because of undesirable effects has been rare.


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