CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Ketoconazole (nizoral) pkge. 200 mg 10 the amount of packaging.
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|(2 R,4 S )-(+)-ketoconazole (top) (2 S,4 R )-(−)-ketoconazole (bottom)|
|Pronunciation||/ ˌ k iː t oʊ ˈ k oʊ n ə ˌ z oʊ l, - z ɒ l /  |
|Trade names||Nizoral, others|
|License data||EU EMA: by INN, US FDA: Ketoconazole|
|Pregnancy category||AU: B3 US: C (Risk not ruled out)|
|Routes of administration||Oral (tablets), topical (cream, shampoo, solution)|
|ATC code||J02AB02 ( WHO ) D01AC08 ( WHO ) G01AF11 ( WHO )|
|Legal status||UK: OTC US: OTC|
|Bioavailability||Oral: 37–97% |
|Protein binding||84 to 99%|
|Metabolism||Extensive liver (predominantly oxidation, O -dealkylation)|
|Metabolites||N -deacetyl ketoconazole|
|Excretion||Biliary (major) and kidney |
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