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Clinical data
Trade namesCymbalta, others [1]
License dataEU  EMA:  by INN, US   FDA: duloxetine
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationBy mouth
Drug classSerotonin–norepinephrine reuptake inhibitor
ATC codeN06AX21 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability~ 50% (32% to 80%)
Protein binding~ 95%
MetabolismLiver, two P450 isozymes, CYP2D6 and CYP1A2
Elimination half-life12 hours
Excretion70% in urine, 20% in feces

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Ymbalta duloxetine is a selective duloxetine hcl cost and norepinephrine reuptake duloxetine hcl cost SNRI antidepressant used to treat depression, generalized anxiety disorder, pain associated with diabetic peripheral neuropathy, fibromyalgia, and chronic musculoskeletal pain.I found this group a few months ago and have started the taper down method listed on here. was on 60mg for 8 years, to 40mg for a year, then down to 30 mg for a month, down to 20 for the last month.

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I am a bit how much is duloxetine now than when on it, but far worse than I was before. I wish I never touch this stuff, I feel like I will never get my life back again, certainly never my career.I'm a pharmacologist, freelance science and medicine writer, educator, and speaker with a passion for public understanding of science and medicine.

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Cymbalta demonstrated statistical superiority over placebo as measured by improvement in the 17-item Hamilton Depression Rating Scale HAM-D total score including both the emotional and somatic symptoms of depression Response and remission rates were also statistically significantly higher with Cymbalta compared with placebo.

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