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Clonidine
Clinical data
Pronunciation/ ˈ k l ɒ n ə d iː n /
Trade namesCatapres, Kapvay, Nexiclon, others
AHFS/Drugs.comMonograph
MedlinePlusa682243
License dataUS   FDA: Clonidine
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationBy mouth, epidural, IV, transdermal, topical
ATC codeC02AC01 ( WHO ) N02CX02 ( WHO ), S01EA04 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability75–95% (oral), 60–70% (transdermal) [2]
Protein binding20–40% [1]
MetabolismLiver to inactive metabolites, [1] 2/3 CYP2D6 [1]
Elimination half-lifeIR: 12–16 hours, [3] 48 hours for repeated dosing [2]
ExcretionUrine (72%) [1]

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