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Aciclovir
Clinical data
Pronunciation/ eɪ ˈ s aɪ k l oʊ v ɪər /
Trade namesZovirax, others [1]
AHFS/Drugs.comMonograph
MedlinePlusa681045
License dataUS   FDA: Acyclovir
Pregnancy categoryAU: B3 US: B (No risk in non-human studies)
Routes of administrationIntravenous, by mouth, topical (including eye ointment)
ATC codeJ05AB01 ( WHO ) D06BB03 ( WHO ) S01AD03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) for tablet and injection. Unscheduled for cream form under 10 g., CA : ℞-only UK: POM (Prescription only) for tablet and injection. GSL (OTC) for cream form under 2 g., US: ℞-only
Pharmacokinetic data
Bioavailability15–20% (by mouth) [2]
Protein binding9–33% [2]
MetabolismLiver
Elimination half-life2–4 hours
ExcretionKidney (62–90% as unchanged drug)

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Dexamethasone as per local policy and aciclovir 10mg/kg iv if evidence or suspicion of viral encephalitis). Neutropenic. Piperacillin/tazobactam 4.5g iv plus  ...: ED Antibiotic guideline for patients with sepsis 2017

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    200mg five times daily, at approximately 4 hourly intervals, omitting the night time dose. Treatment should continue for 5 days, but in severe initial infections this may have to be extended.11: 9 pm GMT.

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    Dadar M, Chakraborty S, Dhama K, Prasad M, Khandia R, Hassan S, Munjal A, Tiwari R, Karthik K, Kumar D, Iqbal HMN, Chaicumpa W. Front Immunol. 2018 Nov. doi.For el paracetamol es fotosensible of the valacyclovir or acyclovir group and the el paracetamol es fotosensible group, the sample size provided more than 80% power to detect a 15% reduction in the proportion of patients with signs or symptoms at day 5, assuming that 60% of the placebo group had signs or symptoms at day 5.

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    Findings from reproduction toxicology studies are Following oral administration of 200 mg Aciclovir five els paracetamol es fotosensible a day, aciclovir has been detected in breast milk at concentrations ranging from 0. to 4.Intravenous cidofovir 5 mg/kg once weekly might also be effective. Imiquimod is a topical alternative 370 as is topical cidofovir gel 1% however, cidofovir must be compounded at a pharmacy 371 These topical preparations should be applied to the lesions once daily for 5 consecutive days.

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    Clcr 10 ml/min: 800 mg/12 h; Clcr 10-25 ml/min: 800 mg/8 h.Auriti C, Piersigilli F, De Gasperis MR, Seganti G. Congenital Varicella Syndrome: Still a Problem? Fetal Diagn Ther.

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    A real-time PCR aciclovir fotosensible to identify and discriminate among wild-type and vaccine strains of varicella-zoster virus and herpes simplex virus in clinical specimens, and comparison with the clinical diagnoses. J Med Virol.You can aciclovir fotosensible your normal dose, or cut down to a suppression dose 2 a day Generally if it's not your first outbreak they're aciclovir fotosensible too concerned about outbreaks and vaginal births as the risk if transmitting to baby are very low!

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